Web代表性论著. 第一作者或通讯作者文章:. (1) Hu X, Zhang J, Lee JM, Chen Z, Hwang D, Park J, Shin ES, Nam CW, Doh JH, Chen S, Yang J, Tanaka N, Kuramitsu S, Matsuo H, Takashima H, Akasaka T, Koo BK, Wang J. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial ... WebMay 29, 2024 · The BK channel, one of the most important potassium channels in CASMCs, plays an important role in regulating the vascular tone of the coronary artery. It has been reported that the BK channel currents account for about 65% of the total potassium channel currents in rat CASMCs.
Trafficking of BK channel subunits controls arterial contractility
Web(A) Coronary arterioles of T2DM patients exhibit diminished BK channel Ca 2+ sensitivity. Left panel: Representative tracings of inside-out single BK channel currents recorded at +60mV in an excised patch of freshly isolated atrial coronary arteriolar myocytes from non-diabetic (Ctrl) and T2DM patients. WebMay 27, 2024 · Moreover, while angiotensin-(1-7) and BK were inversely correlated with homeostasis model assessment, systolic blood pressure, and C-reactive protein, angiotensin I and des-Arg 9-BK were ... ready to come home
Downregulation of AT 2 R Decreases the Responsiveness of BK Ca …
WebFeb 15, 2024 · Preservation of BK channel activity may serve as a potential strategy for the treatment of AT1-AAs-induced maladaptive resistance artery remodeling. Keywords: BK … WebDec 6, 2024 · Aims: The angiotensin II type 1 receptor autoantibody (AT1-AA) leads pathological sustainable vasoconstriction. Large-conductance Ca 2+-and voltage-activated potassium (BK) channel, mainly consist by functional α subunits and modulatory β1 subunits in vascular smooth muscle cells (SMCs), plays a vital role on vascular … WebBK channels in the vascular system are modulated by agents naturally produced in the body, such as angiotensin II (Ang II), high glucose or arachidonic acid (AA) which is modulated in diabetes by oxidative stress (ROS). [10] A weaker voltage sensitivity allows BK channels to function in a wide range of membrane potentials. ready to cook food delivery