Inflammation is known to predispose the development of cancer and tumor progression (79). Tumor cells can produce cytokines and attract immune cells to the tumor microenvironment, promoting a chronic inflammation at the site of the tumor. The cell types present in the tumor microenvironment may define … See more Inflammation is a complex response to microbial infections or tissue damage involving interactions between soluble molecules and … See more The central nervous system (CNS) is an immune-privileged tissue, protected by the blood-brain barrier. Hence, peripheral immune cells do not have access to the brain in physiological circumstances. Besides microglial … See more GPNMB is expressed in all brain regions, but especially in the hippocampal dentate gyrus, choroid plexus, ependyma, periventricular regions, and in layers II and III of the cerebral cortex (50). Besides the brain region, GPNMB … See more GPNMB is an endogenous type 1 transmembrane glycoprotein that was first described in 1995 as more highly expressed in low-metastatic melanoma cell lines (22). … See more
Single-Cell RNA Sequencing of Microglia throughout the Mouse
WebMar 30, 2014 · GPNMB, also known as HGFIN, osteoactivin, and DC-HIL, is a type I membrane glycoprotein involved in various biological processes, including inflammation, invasion and metastasis of malignant tumors, cell differentiation, and tissue regeneration (Rose and Siegel 2010 ). WebNov 12, 2024 · GPNMB staining in microglia was assessed using R&D antibody AF2550. Table 2 List of antibodies and immunostaining methods Full size table Quantitative image analysis Labelled tissue sections were imaged using a Leica Aperio AT2 Brightfield Scanner (Leica Biosystems). Images were analysed using HALO software (Indica Labs, Version … lake havasu city home
Transgenic Overexpression of GPNMB Protects Against …
WebGPNMB, encoding glycoprotein non-metastatic melanoma B, is upregulated at the protein level in ALS patient spinal cord, CSF and sera 37,38 and is expressed by activated microglia 39 . A common... WebJan 1, 2024 · Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. WebMicroglia were initially defined as occupying non-overlapping territories in the healthy brain, but this view is now changing, with improved staining methods showing direct contacts between processes and sometimes cell … askim simhall