The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during mitosis or meiosis that prevents the separation of the duplicated chromosomes (anaphase) until … See more The beginning of metaphase is characterized by the connection of the microtubules to the kinetochores of the chromosomes, as well as the alignment of the chromosomes in the middle of the cell. Each chromatid has … See more The spindle assembly checkpoint (SAC) is an active signal produced by improperly attached kinetochores, which is conserved in all eukaryotes. The SAC stops the cell cycle by negatively regulating CDC20, thereby preventing the activation of the polyubiquitynation … See more • Larsen NA, Al-Bassam J, Wei RR, Harrison SC (January 2007). "Structural analysis of Bub3 interactions in the mitotic spindle checkpoint". Proceedings of the National Academy of … See more • Ted Salmon's lab: dividing cells movies. [1] • Andrea Musacchio's lab: spindle checkpoint schemes. [2] See more Zirkle (in 1970) was one of the first researchers to observe that, when just one chromosome is retarded to arrive at the metaphase plate, anaphase onset is postponed until … See more Cell division: duplication of material and distribution to daughter cells When cells are ready to divide, because cell size is big enough or because they receive the appropriate stimulus, they activate the mechanism to enter into the cell cycle, and they … See more When the spindle checkpoint misfunctions, this can lead to chromosome missegregation, aneuploidy and even tumorigenesis. Transformation occurs and is accelerated when maintenance of genomic integrity breaks down especially at … See more WebDuring mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate …
Knl1 participates in spindle assembly checkpoint signaling in maize - PNAS
Web在细胞分裂过程中,纺锤体组装检验点 (spindle assembly checkpoint,SAC)监控着染色体与纺锤体微管的结合以及有丝分裂中姐妹染色单体或减数分裂同源染色体间的张力,从而保证 … WebThe ‘spindle assembly checkpoint’ or SAC is a term used to describe the complexes of proteins and signaling pathways that prevent anaphase onset until all chromosomes have achieved bi-oriented attachment via their kinetochores to the mitotic spindle and are aligned at the metaphase plate (Figure 4). As such, the SAC is activated upon ... likert scale research paper
A quantitative systems view of the spindle assembly checkpoint
WebAbstract. Abstract The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by … WebJan 23, 2016 · 2.1 Maintaining Spindle Assembly Checkpoint Activity. An important question is whether the SAC is dispensable for unperturbed mitotic progression and only functions … WebJan 11, 2001 · Mitotic spindle assembly checkpoint protein MAD2B. Alternative names. Mitotic arrest deficient 2-like protein 2 (MAD2-like protein 2) REV7 homolog (hREV7) Gene names. Name. MAD2L2. Synonyms. MAD2B, REV7. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. likert scale research instrument